Engineering Photosensory Modules of Non-Opsin-Based Optogenetic Actuators
نویسندگان
چکیده
منابع مشابه
Non-invasive activation of optogenetic actuators.
The manipulation of genetically targeted neurons with light (optogenetics) continues to provide unprecedented avenues into studying the function of the mammalian brain. However, potential translation into the clinical arena faces a number of significant hurdles, foremost among them the need for insertion of optical fibers into the brain to deliver light to opsins expressed on neuronal membranes...
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The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed. Recent advances in understanding microbial opsins have been driven by molecular engineering for optogenetics and by comparative genomics. Here we provide a Primer on these ligh...
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در این پایان نامه، در ابتدا برای مدول ها روی دامنه های پروفر شرایط معادل به دست آورده ایم و خواصی از ددکیند مدول ها روی دامنه های پروفر مشخص کرده ایم. در ادامه برای ددکیند مدول های با تولید متناهی روی حلقه های به طور صحیح بسته شرایط معادل به دست آورده ایم و ددکیند مدول های ضربی را مشخص کرده ایم. گزاره هایی در مورد بعد ددکیند مدول ها بیان کرده ایم. در پایان، قضایای lying over و going down را برا...
15 صفحه اولComparative analysis of optogenetic actuators in cultured astrocytes
Astrocytes modulate synaptic transmission via release of gliotransmitters such as ATP, glutamate, D-serine and L-lactate. One of the main problems when studying the role of astrocytes in vitro and in vivo is the lack of suitable tools for their selective activation. Optogenetic actuators can be used to manipulate astrocytic activity by expression of variants of channelrhodopsin-2 (ChR2) or othe...
متن کاملSea urchin tube feet are photosensory organs that express a rhabdomeric-like opsin and PAX6.
All echinoderms have unique hydraulic structures called tube feet, known for their roles in light sensitivity, respiration, chemoreception and locomotion. In the green sea urchin, the most distal portion of these tube feet contain five ossicles arranged as a light collector with its concave surface facing towards the ambient light. These ossicles are perforated and lined with pigment cells that...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21186522